Membrane lymphotoxin is required for resistance to Theiler's virus infection
نویسندگان
چکیده
منابع مشابه
Membrane lymphotoxin is required for the development of different subpopulations of NK T cells.
The development of lymphoid organs requires membrane-bound lymphotoxin (LT), a heterotrimer containing LTalpha and LTbeta, but the effects of LT on T cell function have not been characterized extensively. Upon TCR cross-linking in vitro, splenocytes from both LTalpha-/- and LTbeta-/- mice failed to produce IL-4 and IL-10 due to a reduction in NK T cells. Concordantly, LTalpha-/- and LTbeta-/- m...
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ژورنال
عنوان ژورنال: International Immunology
سال: 2003
ISSN: 1460-2377
DOI: 10.1093/intimm/mcg094